Radiological Diagnosis Model for Clinically Diagnosed Hypersensitivity Pneumonitis

Document Type : Original Article

Authors

1 Assistant Professor of Radiology, Faculty of Medicine – Cairo University

2 Professor of Radiology, Faculty of Medicine – Cairo University

3 Radiology Department, Shobra General Hospital, Cairo, Egypt

4 Professor of Pulmonology, Faculty of Medicine – Cairo University

Abstract

Introduction: Hypersensitivity Pneumonitis is an immune-mediated interstitial lung disease that manifests in susceptible patients following exposure to an inciting agent(s). It is classified based on symptoms behavior and disease course into three categories acute, subacute and chronic. Diagnosis of Hypersensitivity Pneumonitis is challenging because of the lack of any unique radiological finding distinguishing it from other interstitial lung disease. Hypersensitivity Pneumonitis diagnosis depends on a high level of clinical suspicion, the recognition of antigen exposure, and a constellation of, radiologic, laboratory, and pathologic findings. Creating a diagnostic model including patient age, history of antigen exposure and radiological findings can increase specificity for diagnosis of hypersensitivity pneumonitis. Results: Females represented the vast majority of the included patients accounting for 90% of them. All (100%) of the included patients presented with cough and dyspnea predominantly of grade II (36.7%). Also, all (100%) of included patients reported current status of raising birds. There was a statistically positive and moderate correlation between the patient's dyspnea score and their global CT score with p value 0.005. Conclusion: Radiological diagnostic model with clinical correlation are highly specific diagnostic parameters for hypersensitivity pneumonitis, it offers a high level of inter-observer agreement and internal consistency.

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