Studying the correlation between transforming growth factor β1 and chitinase-3-like-1 in assessment of bronchial asthma severity

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Abstract

Background
Chronic inflammation and airway remodeling have important roles in asthma pathophysiology. Transforming growth factor β1 (TGF-β1) and YKL-40 play a very important role in the pathogenesis of asthma.
Aim
The aim of this work was to find noninvasive biomarkers that may enable us to assess asthma severity as a surrogate for invasive bronchial mucosa biopsy. Therefore, we studied the correlation between TGF-β1 and YKL-40 and asthma severity.
Patients and method
The work was done on 40 patients with asthma who were classified into two groups: 20 patients with mild asthma and 20 patients with severe but stable asthma. A third group of 20 normal participants was taken as control. Immunoglobulin E total, YKL-40, and TGF-β1 were determined in serum of all studied groups.
Results
The results showed highly significant increased serum TGF-β1 and serum YKL-40 in patients with asthma compared with control group, and they were positively correlated with disease severity.
Conclusion
We conclude that increased serum levels of TGF-β1 and YKL-40 may be a biological characteristic of asthma exacerbation.

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